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KMID : 0545120170270040739
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Journal of Microbiology and Biotechnology
2017 Volume.27 No. 4 p.739 ~ p.746
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Oral Delivery of Probiotics Using pH-Sensitive Tablets
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Jiang Tao
Li Hui-Shan
Han Geon-Goo
Singh Bijay
Kang Sang-Kee
Bok Jin-Duck
Kim Dae-Duk
Hong Zhong-Shan
Choi Yun-Jaie
Cho Chong-Su
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Abstract
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As alternatives to antibiotics in livestocks, probiotics have been used, although most of them in the form of liquid or semisolid formulations, which show low cell viability after oral administration. Therefore, suitable dry dosage forms should be developed for livestocks to protect probiotics against the low pH in the stomach such that the products have higher probiotics survivability. Here, in order to develop a dry dosage forms of probiotics for poultry, we used hydroxypropyl methylcellulose phthalate 55 (HPMCP 55) as a tablet-forming matrix to develop probiotics in a tablet form for poultry. Here, we made three different kinds of probiotics-loaded tablet under different compression forces and investigated their characteristics based on their survivability, morphology, disintegration time, and kinetics in simulated gastrointestinal fluid. The results indicated that the probiotics formulated in the tablets displayed higher survival rates in acidic gastric conditions than probiotics in solution. Rapid release of the probiotics from the tablets occurred in simulated intestinal fluid because of fast swelling of the tablets in neutral pH. As a matrix of tablet, HPMCP 55 provided good viability of probiotics after 6 months under refrigeration. Moreover, after oral administration of probiotics-loaded tablets to chicken, more viable probiotics were observed, than with solution type, through several digestive areas of chicken by the tablets.
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KEYWORD
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Probiotics, hydroxypropyl methylcellulose phthalate, oral delivery, poultry, pH-sensitive tablet
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